Learning Representations of Instruments for Partial Identification of Treatment Effects

Authors: Jonas Schweisthal, Dennis Frauen, Maresa Schröder, Konstantin Hess, Niki Kilbertus, Stefan Feuerriegel

ICML 2025 | Venue PDF | Archive PDF | Plain Text | LLM Run Details

Reproducibility Variable Result LLM Response
Research Type Experimental We further perform extensive experiments to demonstrate the effectiveness across various settings. Overall, our procedure offers a novel path for practitioners to make use of potentially high-dimensional instruments (e.g., as in Mendelian randomization).
Researcher Affiliation Academia 1 LMU Munich 2 Munich Center for Machine Learning (MCML) 3 School of Computation, Information and Technology, TU Munich 4 Helmholtz Munich. Correspondence to: Jonas Schweisthal <EMAIL>.
Pseudocode Yes Algorithm 1: Two-stage learner for estimating bounds with complex instruments
Open Source Code Yes 2Code is available at https://github.com/JSchweisthal/ComplexPartialIdentif.
Open Datasets Yes We provide results using real-world data from an ADJUVANT chemotherapy study (Liu et al., 2021) as provided in https://github.com/cancer-oncogenomics/minerva-adjuvant-nsclc/tree/v1.0.0.
Dataset Splits Yes To create the simulated data used in Sec. 6, we sample n = 2000 from the data-generating process above. We then split the data into train (40%), val (20%), and test (40%) sets such that the bounds and deviation can be calculated on the same amount of data for training and testing.
Hardware Specification Yes Each training run of the experiments could be performed on a CPU with 8 cores in under 15 minutes.
Software Dependencies No We use PyTorch Lightning for implementation. Each training run of the experiments could be performed on a CPU with 8 cores in under 15 minutes.
Experiment Setup Yes For all models, we use the Adam optimizer with a learning rate of 0.03. We train our models for a maximum of 100 epochs and apply early stopping. For our method, we fixed λ = 1 and performed random search to tune for [0, 1] for γ.